The dual epigenetic role of PRMT5 in acute myeloid leukemia: gene activation and repression via hist...
The dual epigenetic role of PRMT5 in acute myeloid leukemia: gene activation and repression via histone arginine methylation
About this item
Full title
Author / Creator
Tarighat, S S , Santhanam, R , Frankhouser, D , Radomska, H S , Lai, H , Anghelina, M , Wang, H , Huang, X , Alinari, L , Walker, A , Caligiuri, M A , Croce, C M , Li, L , Garzon, R , Li, C , Baiocchi, R A and Marcucci, G
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Changes in the enzymatic activity of protein arginine methyltransferase (PRMT) 5 have been associated with cancer; however, the protein’s role in acute myeloid leukemia (AML) has not been fully evaluated. Here, we show that increased PRMT5 activity enhanced AML growth
in vitro
and
in vivo
while PRMT5 downregulation reduced it. In AML ce...
Alternative Titles
Full title
The dual epigenetic role of PRMT5 in acute myeloid leukemia: gene activation and repression via histone arginine methylation
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8034866
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8034866
Other Identifiers
ISSN
0887-6924
E-ISSN
1476-5551
DOI
10.1038/leu.2015.308
