Soluble α-synuclein–antibody complexes activate the NLRP3 inflammasome in hiPSC-derived microglia
Soluble α-synuclein–antibody complexes activate the NLRP3 inflammasome in hiPSC-derived microglia
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Author / Creator
Trudler, Dorit , Nazor, Kristopher L. , Eisele, Yvonne S. , Grabauskas, Titas , Dolatabadi, Nima , Parker, James , Sultan, Abdullah , Zhong, Zhenyu , Goodwin, Marshall S. , Levites, Yona , Golde, Todd E. , Kelly, Jeffery W. , Sierks, Michael R. , Schork, Nicholas J. , Karin, Michael , Ambasudhan, Rajesh and Lipton, Stuart A.
Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
Parkinson’s disease is characterized by accumulation of α-synuclein (αSyn). Release of oligomeric/fibrillar αSyn from damaged neurons may potentiate neuronal death in part via microglial activation. Heretofore, it remained unknown if oligomeric/fibrillar αSyn could activate the nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) fam...
Alternative Titles
Full title
Soluble α-synuclein–antibody complexes activate the NLRP3 inflammasome in hiPSC-derived microglia
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8054017
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8054017
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.2025847118
