Mutations in LZTR1 drive human disease by dysregulating RAS ubiquitination
Mutations in LZTR1 drive human disease by dysregulating RAS ubiquitination
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Author / Creator
Steklov, M. , Pandolfi, S. , Baietti, M. F. , Batiuk, A. , Carai, P. , Najm, P. , Zhang, M. , Jang, H. , Renzi, F. , Cai, Y. , Abbasi Asbagh, L. , Pastor, T. , De Troyer, M. , Simicek, M. , Radaelli, E. , Brems, H. , Legius, E. , Tavernier, J. , Gevaert, K. , Impens, F. , Messiaen, L. , Nussinov, R. , Heymans, S. , Eyckerman, S. and Sablina, A. A.
Publisher
United States: The American Association for the Advancement of Science
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Language
English
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United States: The American Association for the Advancement of Science
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Contents
The protein LZTR1 is mutated in human cancers and developmental diseases. Work from two groups now converges to implicate the protein in regulating signaling by the small guanosine triphosphatase RAS. Steklov
et al.
showed that mice haploinsufficient for LZTR1 recapitulated aspects of the human disease Noonan syndrome. Their biochemical studi...
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Full title
Mutations in LZTR1 drive human disease by dysregulating RAS ubiquitination
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8058620
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8058620
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ISSN
0036-8075,1095-9203
E-ISSN
1095-9203
DOI
10.1126/science.aap7607
