Epigenetic loss of AOX1 expression via EZH2 leads to metabolic deregulations and promotes bladder ca...
Epigenetic loss of AOX1 expression via EZH2 leads to metabolic deregulations and promotes bladder cancer progression
About this item
Full title
Author / Creator
Vantaku, Venkatrao , Putluri, Vasanta , Bader, David A. , Maity, Suman , Ma, Jing , Arnold, James M. , Rajapakshe, Kimal , Donepudi, Sri Ramya , von Rundstedt, Friedrich-Carl , Devarakonda, Vaishnavi , Dubrulle, Julien , Karanam, Balasubramanyam , McGuire, Sean E. , Stossi, Fabio , Jain, Abhinav K. , Coarfa, Cristian , Cao, Qi , Sikora, Andrew G. , Villanueva, Hugo , Kavuri, Shyam M. , Lotan, Yair , Sreekumar, Arun and Putluri, Nagireddy
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Advanced Bladder Cancer (BLCA) remains a clinical challenge that lacks effective therapeutic measures. Here, we show that distinct, stage-wise metabolic alterations in BLCA are associated with the loss of function of aldehyde oxidase (AOX1). AOX1 associated metabolites have a high predictive value for advanced BLCA and our findings demonstrate that...
Alternative Titles
Full title
Epigenetic loss of AOX1 expression via EZH2 leads to metabolic deregulations and promotes bladder cancer progression
Authors, Artists and Contributors
Author / Creator
Putluri, Vasanta
Bader, David A.
Maity, Suman
Ma, Jing
Arnold, James M.
Rajapakshe, Kimal
Donepudi, Sri Ramya
von Rundstedt, Friedrich-Carl
Devarakonda, Vaishnavi
Dubrulle, Julien
Karanam, Balasubramanyam
McGuire, Sean E.
Stossi, Fabio
Jain, Abhinav K.
Coarfa, Cristian
Cao, Qi
Sikora, Andrew G.
Villanueva, Hugo
Kavuri, Shyam M.
Lotan, Yair
Sreekumar, Arun
Putluri, Nagireddy
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8058741
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8058741
Other Identifiers
ISSN
0950-9232
E-ISSN
1476-5594
DOI
10.1038/s41388-019-0902-7
