Mutations Q93H and E97K in TPM2 Disrupt Ca-Dependent Regulation of Actin Filaments
Mutations Q93H and E97K in TPM2 Disrupt Ca-Dependent Regulation of Actin Filaments
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Switzerland: MDPI AG
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English
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Switzerland: MDPI AG
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Tropomyosin is a two-chain coiled coil protein, which together with the troponin complex controls interactions of actin with myosin in a Ca2+-dependent manner. In fast skeletal muscle, the contractile actin filaments are regulated by tropomyosin isoforms Tpm1.1 and Tpm2.2, which form homo- and heterodimers. Mutations in the TPM2 gene encoding isofo...
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Full title
Mutations Q93H and E97K in TPM2 Disrupt Ca-Dependent Regulation of Actin Filaments
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8070786
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8070786
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ISSN
1422-0067,1661-6596
E-ISSN
1422-0067
DOI
10.3390/ijms22084036
