REV-ERB in GABAergic neurons controls diurnal hepatic insulin sensitivity
REV-ERB in GABAergic neurons controls diurnal hepatic insulin sensitivity
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Author / Creator
Ding, Guolian , Li, Xin , Hou, Xinguo , Zhou, Wenjun , Gong, Yingyun , Liu, Fuqiang , He, Yanlin , Song, Jia , Wang, Jing , Basil, Paul , Li, Wenbo , Qian, Sichong , Saha, Pradip , Wang, Jinbang , Cui, Chen , Yang, Tingting , Zou, Kexin , Han, Younghun , Amos, Christopher I. , Xu, Yong , Chen, Li and Sun, Zheng
Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
Systemic insulin sensitivity shows a diurnal rhythm with a peak upon waking
1
,
2
. The molecular mechanism that underlies this temporal pattern is unclear. Here we show that the nuclear receptors REV-ERB-α and REV-ERB-β (referred to here as ‘REV-ERB’) in the GABAergic (γ-aminobutyric acid-producing) neurons in the suprachiasmatic nucle...
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Full title
REV-ERB in GABAergic neurons controls diurnal hepatic insulin sensitivity
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8085086
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8085086
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-021-03358-w
