ISG15-dependent activation of the sensor MDA5 is antagonized by the SARS-CoV-2 papain-like protease...
ISG15-dependent activation of the sensor MDA5 is antagonized by the SARS-CoV-2 papain-like protease to evade host innate immunity
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Activation of the RIG-I-like receptors, retinoic-acid inducible gene I (RIG-I) and melanoma differentiation-associated protein 5 (MDA5), establishes an antiviral state by upregulating interferon (IFN)-stimulated genes (ISGs). Among these is ISG15, the mechanistic roles of which in innate immunity still remain enigmatic. In the present study, we rep...
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ISG15-dependent activation of the sensor MDA5 is antagonized by the SARS-CoV-2 papain-like protease to evade host innate immunity
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8103894
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8103894
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ISSN
2058-5276
E-ISSN
2058-5276
DOI
10.1038/s41564-021-00884-1
