The Dysregulation of OGT/OGA Cycle Mediates Tau and APP Neuropathology in Down Syndrome
The Dysregulation of OGT/OGA Cycle Mediates Tau and APP Neuropathology in Down Syndrome
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Publisher
Cham: Springer International Publishing
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Language
English
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Publisher
Cham: Springer International Publishing
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Contents
Protein O-GlcNAcylation is a nutrient-related post-translational modification that, since its discovery some 30 years ago, has been associated with the development of neurodegenerative diseases. As reported in Alzheimer’s disease (AD), flaws in the cerebral glucose uptake translate into reduced hexosamine biosynthetic pathway flux and subsequently...
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Full title
The Dysregulation of OGT/OGA Cycle Mediates Tau and APP Neuropathology in Down Syndrome
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8116370
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8116370
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ISSN
1933-7213,1878-7479
E-ISSN
1878-7479
DOI
10.1007/s13311-020-00978-4
