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Microglial Gi-dependent dynamics regulate brain network hyperexcitability

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Microglial Gi-dependent dynamics regulate brain network hyperexcitability

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8118167

Microglial Gi-dependent dynamics regulate brain network hyperexcitability

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Publisher

New York: Nature Publishing Group US

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Scope and Contents

Contents

Microglial surveillance is a key feature of brain physiology and disease. Here, we found that G
i
-dependent microglial dynamics prevent neuronal network hyperexcitability. By generating Mg
PTX
mice to genetically inhibit G
i
in microglia, we show that sustained reduction of microglia brain surveillance and directed process motili...

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Full title

Microglial Gi-dependent dynamics regulate brain network hyperexcitability

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Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8118167

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8118167

Other Identifiers

ISSN

1097-6256

E-ISSN

1546-1726

DOI

10.1038/s41593-020-00756-7

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