Design and Rationale of the Global Phase 3 NEURO-TTRansform Study of Antisense Oligonucleotide AKCEA...
Design and Rationale of the Global Phase 3 NEURO-TTRansform Study of Antisense Oligonucleotide AKCEA-TTR-LRx (ION-682884-CS3) in Hereditary Transthyretin-Mediated Amyloid Polyneuropathy
About this item
Full title
Author / Creator
Coelho, Teresa , Ando, Yukio , Benson, Merrill D. , Berk, John L. , Waddington-Cruz, Márcia , Dyck, Peter J. , Gillmore, Julian D. , Khella, Sami L. , Litchy, William J. , Obici, Laura , Monteiro, Cecilia , Tai, Li-Jung , Viney, Nicholas J. , Buchele, Gustavo , Brambatti, Michela , Jung, Shiangtung W. , St. L. O’Dea, Louis , Tsimikas, Sotirios , Schneider, Eugene , Geary, Richard S. , Monia, Brett P. and Gertz, Morie
Publisher
Cheshire: Springer Healthcare
Journal title
Language
English
Formats
Publication information
Publisher
Cheshire: Springer Healthcare
Subjects
More information
Scope and Contents
Contents
Introduction
AKCEA-TTR-L
Rx
is a ligand-conjugated antisense (LICA) drug in development for the treatment of hereditary transthyretin amyloidosis (hATTR), a fatal disease caused by mutations in the transthyretin (
TTR
) gene. AKCEA-TTR-L
Rx
shares the same nucleotide sequence as inotersen, an antisense medicine approved for use...
Alternative Titles
Full title
Design and Rationale of the Global Phase 3 NEURO-TTRansform Study of Antisense Oligonucleotide AKCEA-TTR-LRx (ION-682884-CS3) in Hereditary Transthyretin-Mediated Amyloid Polyneuropathy
Authors, Artists and Contributors
Author / Creator
Ando, Yukio
Benson, Merrill D.
Berk, John L.
Waddington-Cruz, Márcia
Dyck, Peter J.
Gillmore, Julian D.
Khella, Sami L.
Litchy, William J.
Obici, Laura
Monteiro, Cecilia
Tai, Li-Jung
Viney, Nicholas J.
Buchele, Gustavo
Brambatti, Michela
Jung, Shiangtung W.
St. L. O’Dea, Louis
Tsimikas, Sotirios
Schneider, Eugene
Geary, Richard S.
Monia, Brett P.
Gertz, Morie
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8140170
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8140170
Other Identifiers
ISSN
2193-8253
E-ISSN
2193-6536
DOI
10.1007/s40120-021-00235-6
