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Functional expression of complement factor I following AAV-mediated gene delivery in the retina of m...

Functional expression of complement factor I following AAV-mediated gene delivery in the retina of m...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8149295

Functional expression of complement factor I following AAV-mediated gene delivery in the retina of mice and human cells

About this item

Full title

Functional expression of complement factor I following AAV-mediated gene delivery in the retina of mice and human cells

Publisher

London: Nature Publishing Group UK

Journal title

Gene therapy, 2021-05, Vol.28 (5), p.265-276

Language

English

Formats

Publication information

Publisher

London: Nature Publishing Group UK

More information

Scope and Contents

Contents

Dry age-related macular degeneration (AMD) is characterised by loss of central vision and currently has no approved medical treatment. Dysregulation of the complement system is thought to play an important role in disease pathology and supplementation of Complement Factor I (CFI), a key regulator of the complement system, has the potential to provi...

Alternative Titles

Full title

Functional expression of complement factor I following AAV-mediated gene delivery in the retina of mice and human cells

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8149295

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8149295

Other Identifiers

ISSN

0969-7128,1476-5462

E-ISSN

1476-5462

DOI

10.1038/s41434-021-00239-9

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