Computational Investigation Identified Potential Chemical Scaffolds for Heparanase as Anticancer The...
Computational Investigation Identified Potential Chemical Scaffolds for Heparanase as Anticancer Therapeutics
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Publisher
Basel: MDPI AG
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Language
English
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Basel: MDPI AG
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Contents
Heparanase (Hpse) is an endo-β-D-glucuronidase capable of cleaving heparan sulfate side chains. Its upregulated expression is implicated in tumor growth, metastasis and angiogenesis, thus making it an attractive target in cancer therapeutics. Currently, a few small molecule inhibitors have been reported to inhibit Hpse, with promising oral administ...
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Full title
Computational Investigation Identified Potential Chemical Scaffolds for Heparanase as Anticancer Therapeutics
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8157885
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8157885
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ISSN
1422-0067,1661-6596
E-ISSN
1422-0067
DOI
10.3390/ijms22105311
