Genome-wide screens uncover KDM2B as a modifier of protein binding to heparan sulfate
Genome-wide screens uncover KDM2B as a modifier of protein binding to heparan sulfate
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Author / Creator
Weiss, Ryan J. , Spahn, Philipp N. , Chiang, Austin W. T. , Liu, Qing , Li, Jing , Hamill, Kristina M. , Rother, Sandra , Clausen, Thomas M. , Hoeksema, Marten A. , Timm, Bryce M. , Godula, Kamil , Glass, Christopher K. , Tor, Yitzhak , Gordts, Philip L. S. M. , Lewis, Nathan E. and Esko, Jeffrey D.
Publisher
New York: Nature Publishing Group US
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English
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Publisher
New York: Nature Publishing Group US
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Contents
Heparan sulfate (HS) proteoglycans bind extracellular proteins that participate in cell signaling, attachment and endocytosis. These interactions depend on the arrangement of sulfated sugars in the HS chains generated by well-characterized biosynthetic enzymes; however, the regulation of these enzymes is largely unknown. We conducted genome-wide CR...
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Full title
Genome-wide screens uncover KDM2B as a modifier of protein binding to heparan sulfate
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8159865
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8159865
Other Identifiers
ISSN
1552-4450
E-ISSN
1552-4469
DOI
10.1038/s41589-021-00776-9
