Cell lineage tracing links ERα loss in Erbb2-positive breast cancers to the arising of a highly aggr...
Cell lineage tracing links ERα loss in Erbb2-positive breast cancers to the arising of a highly aggressive breast cancer subtype
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Full title
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Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
HER2-positive (HER2⁺) breast cancers (BrCs) contain approximately equal numbers of ERα⁺HER2⁺ and ERα⁻HER2⁺ cases. An enduring obstacle is the unclear cell lineage-related characteristics of these BrCs. Although ERα⁺HER2⁺ BrCs could lose ERα to become ERα⁻HER2⁺ BrCs, direct evidence is missing. To investigate ERα dependencies and their implications...
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Full title
Cell lineage tracing links ERα loss in Erbb2-positive breast cancers to the arising of a highly aggressive breast cancer subtype
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8166171
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8166171
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.2100673118
