Hepatocyte-specific deletion of XBP1 sensitizes mice to liver injury through hyperactivation of IRE1...
Hepatocyte-specific deletion of XBP1 sensitizes mice to liver injury through hyperactivation of IRE1α
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
X-box binding protein-1 (XBP1) is a transcription factor that plays a central role in controlling cellular responses to endoplasmic reticulum (ER) stress. Under stress conditions, the transcriptionally active form of XBP1 is generated via splicing of
Xbp1
mRNA by the ER-resident protein inositol-requiring enzyme-1 (IRE1α). Genetic deletion of...
Alternative Titles
Full title
Hepatocyte-specific deletion of XBP1 sensitizes mice to liver injury through hyperactivation of IRE1α
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8166833
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8166833
Other Identifiers
ISSN
1350-9047
E-ISSN
1476-5403
DOI
10.1038/s41418-020-00671-1
