Spinal subpial delivery of AAV9 enables widespread gene silencing and blocks motoneuron degeneration...
Spinal subpial delivery of AAV9 enables widespread gene silencing and blocks motoneuron degeneration in ALS
About this item
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Author / Creator
Bravo-Hernandez, Mariana , Tadokoro, Takahiro , Navarro, Michael R. , Platoshyn, Oleksandr , Kobayashi, Yoshiomi , Marsala, Silvia , Miyanohara, Atsushi , Juhas, Stefan , Juhasova, Jana , Skalnikova, Helena , Tomori, Zoltan , Vanicky, Ivo , Studenovska, Hana , Proks, Vladimir , Chen, PeiXi , Govea-Perez, Noe , Ditsworth, Dara , Ciacci, Joseph D. , Gao, Shang , Zhu, Wenlian , Ahrens, Eric T. , Driscoll, Shawn P. , Glenn, Thomas D. , McAlonis-Downes, Melissa , Da Cruz, Sandrine , Pfaff, Samuel L. , Kaspar, Brian K. , Cleveland, Don W. and Marsala, Martin
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
Gene silencing with virally delivered shRNA represents a promising approach for treatment of inherited neurodegenerative disorders. In the present study we develop a subpial technique, which we show in adult animals successfully delivers adeno-associated virus (AAV) throughout the cervical, thoracic and lumbar spinal cord, as well as brain motor ce...
Alternative Titles
Full title
Spinal subpial delivery of AAV9 enables widespread gene silencing and blocks motoneuron degeneration in ALS
Authors, Artists and Contributors
Author / Creator
Tadokoro, Takahiro
Navarro, Michael R.
Platoshyn, Oleksandr
Kobayashi, Yoshiomi
Marsala, Silvia
Miyanohara, Atsushi
Juhas, Stefan
Juhasova, Jana
Skalnikova, Helena
Tomori, Zoltan
Vanicky, Ivo
Studenovska, Hana
Proks, Vladimir
Chen, PeiXi
Govea-Perez, Noe
Ditsworth, Dara
Ciacci, Joseph D.
Gao, Shang
Zhu, Wenlian
Ahrens, Eric T.
Driscoll, Shawn P.
Glenn, Thomas D.
McAlonis-Downes, Melissa
Da Cruz, Sandrine
Pfaff, Samuel L.
Kaspar, Brian K.
Cleveland, Don W.
Marsala, Martin
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8171115
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8171115
Other Identifiers
ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/s41591-019-0674-1
