Loss of furin cleavage site attenuates SARS-CoV-2 pathogenesis
Loss of furin cleavage site attenuates SARS-CoV-2 pathogenesis
About this item
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Author / Creator
Johnson, Bryan A. , Xie, Xuping , Bailey, Adam L. , Kalveram, Birte , Lokugamage, Kumari G. , Muruato, Antonio , Zou, Jing , Zhang, Xianwen , Juelich, Terry , Smith, Jennifer K. , Zhang, Lihong , Bopp, Nathen , Schindewolf, Craig , Vu, Michelle , Vanderheiden, Abigail , Winkler, Emma S. , Swetnam, Daniele , Plante, Jessica A. , Aguilar, Patricia , Plante, Kenneth S. , Popov, Vsevolod , Lee, Benhur , Weaver, Scott C. , Suthar, Mehul S. , Routh, Andrew L. , Ren, Ping , Ku, Zhiqiang , An, Zhiqiang , Debbink, Kari , Diamond, Michael S. , Shi, Pei-Yong , Freiberg, Alexander N. and Menachery, Vineet D.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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More information
Scope and Contents
Contents
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)—a new coronavirus that has led to a worldwide pandemic
1
—has a furin cleavage site (PRRAR) in its spike protein that is absent in other group-2B coronaviruses
2
. To explore whether the furin cleavage site contributes to infection and pathogenesis in this virus, we generated...
Alternative Titles
Full title
Loss of furin cleavage site attenuates SARS-CoV-2 pathogenesis
Authors, Artists and Contributors
Author / Creator
Xie, Xuping
Bailey, Adam L.
Kalveram, Birte
Lokugamage, Kumari G.
Muruato, Antonio
Zou, Jing
Zhang, Xianwen
Juelich, Terry
Smith, Jennifer K.
Zhang, Lihong
Bopp, Nathen
Schindewolf, Craig
Vu, Michelle
Vanderheiden, Abigail
Winkler, Emma S.
Swetnam, Daniele
Plante, Jessica A.
Aguilar, Patricia
Plante, Kenneth S.
Popov, Vsevolod
Lee, Benhur
Weaver, Scott C.
Suthar, Mehul S.
Routh, Andrew L.
Ren, Ping
Ku, Zhiqiang
An, Zhiqiang
Debbink, Kari
Diamond, Michael S.
Shi, Pei-Yong
Freiberg, Alexander N.
Menachery, Vineet D.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8175039
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8175039
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-021-03237-4
