Cross-platform validation of neurotransmitter release impairments in schizophrenia patient-derived N...
Cross-platform validation of neurotransmitter release impairments in schizophrenia patient-derived NRXN1-mutant neurons
About this item
Full title
Author / Creator
Pak, ChangHui , Danko, Tamas , Mirabella, Vincent R. , Wang, Jinzhao , Liu, Yingfei , Vangipuram, Madhuri , Grieder, Sarah , Zhang, Xianglong , Ward, Thomas , Huang, Yu-Wen Alvin , Jin, Kang , Dexheimer, Philip , Bardes, Eric , Mitelpunkt, Alexis , Ma, Junyi , McLachlan, Michael , Moore, Jennifer C. , Qu, Pingping , Purmann, Carolin , Dage, Jeffrey L. , Swanson, Bradley J. , Urban, Alexander E. , Aronow, Bruce J. , Pang, Zhiping P. , Levinson, Douglas F. , Wernig, Marius and Südhof, Thomas C.
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
Heterozygous NRXN1 deletions constitute the most prevalent currently known single-gene mutation associated with schizophrenia, and additionally predispose to multiple other neurodevelopmental disorders. Engineered heterozygous NRXN1 deletions impaired neurotransmitter release in human neurons, suggesting a synaptic pathophysiological mechanism. Uti...
Alternative Titles
Full title
Cross-platform validation of neurotransmitter release impairments in schizophrenia patient-derived NRXN1-mutant neurons
Authors, Artists and Contributors
Author / Creator
Danko, Tamas
Mirabella, Vincent R.
Wang, Jinzhao
Liu, Yingfei
Vangipuram, Madhuri
Grieder, Sarah
Zhang, Xianglong
Ward, Thomas
Huang, Yu-Wen Alvin
Jin, Kang
Dexheimer, Philip
Bardes, Eric
Mitelpunkt, Alexis
Ma, Junyi
McLachlan, Michael
Moore, Jennifer C.
Qu, Pingping
Purmann, Carolin
Dage, Jeffrey L.
Swanson, Bradley J.
Urban, Alexander E.
Aronow, Bruce J.
Pang, Zhiping P.
Levinson, Douglas F.
Wernig, Marius
Südhof, Thomas C.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8179243
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8179243
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.2025598118
