Regulation of PD-L1 expression is a novel facet of cyclic-AMP-mediated immunosuppression
Regulation of PD-L1 expression is a novel facet of cyclic-AMP-mediated immunosuppression
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London: Nature Publishing Group UK
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English
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London: Nature Publishing Group UK
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Cyclic-AMP (cAMP) exerts suppressive effects in the innate and adaptive immune system. The PD-1/PD-L1 immune checkpoint downregulates T-cell activity. Here, we examined if these two immunosuppressive nodes intersect. Using normal and malignant lymphocytes from humans, and the phosphodiesterase 4b (Pde4b) knockout mouse, we found that cAMP induces
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Regulation of PD-L1 expression is a novel facet of cyclic-AMP-mediated immunosuppression
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8187478
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8187478
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ISSN
0887-6924
E-ISSN
1476-5551
DOI
10.1038/s41375-020-01105-0
