HIF-2α activation potentiates oxidative cell death in colorectal cancers by increasing cellular iron
HIF-2α activation potentiates oxidative cell death in colorectal cancers by increasing cellular iron
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Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
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Publisher
United States: American Society for Clinical Investigation
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Contents
Hypoxia is a hallmark of solid tumors that promotes cell growth, survival, and metastasis and confers resistance to chemo and radiotherapies. Hypoxic responses are largely mediated by the transcription factors hypoxia-inducible factor 1α (HIF-1α) and HIF-2α. Our work demonstrates that HIF-2α is essential for colorectal cancer (CRC) progression. How...
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Full title
HIF-2α activation potentiates oxidative cell death in colorectal cancers by increasing cellular iron
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8203462
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8203462
Other Identifiers
ISSN
1558-8238,0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI143691
