Log in to save to my catalogue

HIF-1α is a negative regulator of interferon regulatory factors: Implications for interferon product...

HIF-1α is a negative regulator of interferon regulatory factors: Implications for interferon product...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8256008

HIF-1α is a negative regulator of interferon regulatory factors: Implications for interferon production by hypoxic monocytes

About this item

Full title

HIF-1α is a negative regulator of interferon regulatory factors: Implications for interferon production by hypoxic monocytes

Publisher

United States: National Academy of Sciences

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2021-06, Vol.118 (26), p.1-10

Language

English

Formats

Publication information

Publisher

United States: National Academy of Sciences

More information

Scope and Contents

Contents

Patients with severe COVID-19 infection exhibit a low level of oxygen in affected tissue and blood. To understand the pathophysiology of COVID-19 infection, it is therefore necessary to understand cell function during hypoxia. We investigated aspects of human monocyte activation under hypoxic conditions. HMGB1 is an alarmin released by stressed cel...

Alternative Titles

Full title

HIF-1α is a negative regulator of interferon regulatory factors: Implications for interferon production by hypoxic monocytes

Authors, Artists and Contributors

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8256008

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8256008

Other Identifiers

ISSN

0027-8424,1091-6490

E-ISSN

1091-6490

DOI

10.1073/pnas.2106017118

How to access this item