miR-10a as a therapeutic target and predictive biomarker for MDM2 inhibition in acute myeloid leukem...
miR-10a as a therapeutic target and predictive biomarker for MDM2 inhibition in acute myeloid leukemia
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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Contents
Pharmacological inhibition of MDM2/4, which activates the critical tumor suppressor p53, has been gaining increasing interest as a strategy for the treatment of acute myeloid leukemia (AML). While clinical trials of MDM2 inhibitors have shown promise, responses have been confined to largely molecularly undefined patients, indicating that new biomar...
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miR-10a as a therapeutic target and predictive biomarker for MDM2 inhibition in acute myeloid leukemia
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8257503
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8257503
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ISSN
0887-6924
E-ISSN
1476-5551
DOI
10.1038/s41375-020-01095-z
