Regulation of ADAM10 by the TspanC8 Family of Tetraspanins and Their Therapeutic Potential
Regulation of ADAM10 by the TspanC8 Family of Tetraspanins and Their Therapeutic Potential
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Publisher
Switzerland: MDPI AG
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Language
English
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Publisher
Switzerland: MDPI AG
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Contents
The ubiquitously expressed transmembrane protein a disintegrin and metalloproteinase 10 (ADAM10) functions as a “molecular scissor”, by cleaving the extracellular regions from its membrane protein substrates in a process termed ectodomain shedding. ADAM10 is known to have over 100 substrates including Notch, amyloid precursor protein, cadherins, an...
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Full title
Regulation of ADAM10 by the TspanC8 Family of Tetraspanins and Their Therapeutic Potential
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8268256
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8268256
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ISSN
1422-0067,1661-6596
E-ISSN
1422-0067
DOI
10.3390/ijms22136707
