Dnmt1 has de novo activity targeted to transposable elements
Dnmt1 has de novo activity targeted to transposable elements
About this item
Full title
Author / Creator
Haggerty, Chuck , Kretzmer, Helene , Riemenschneider, Christina , Kumar, Abhishek Sampath , Mattei, Alexandra L. , Bailly, Nina , Gottfreund, Judith , Giesselmann, Pay , Weigert, Raha , Brändl, Björn , Giehr, Pascal , Buschow, René , Galonska, Christina , von Meyenn, Ferdinand , Pappalardi, Melissa B. , McCabe, Michael T. , Wittler, Lars , Giesecke-Thiel, Claudia , Mielke, Thorsten , Meierhofer, David , Timmermann, Bernd , Müller, Franz-Josef , Walter, Jörn and Meissner, Alexander
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
DNA methylation plays a critical role during development, particularly in repressing retrotransposons. The mammalian methylation landscape is dependent on the combined activities of the canonical maintenance enzyme Dnmt1 and the de novo Dnmts, 3a and 3b. Here, we demonstrate that Dnmt1 displays de novo methylation activity in vitro and in vivo with...
Alternative Titles
Full title
Dnmt1 has de novo activity targeted to transposable elements
Authors, Artists and Contributors
Author / Creator
Kretzmer, Helene
Riemenschneider, Christina
Kumar, Abhishek Sampath
Mattei, Alexandra L.
Bailly, Nina
Gottfreund, Judith
Giesselmann, Pay
Weigert, Raha
Brändl, Björn
Giehr, Pascal
Buschow, René
Galonska, Christina
von Meyenn, Ferdinand
Pappalardi, Melissa B.
McCabe, Michael T.
Wittler, Lars
Giesecke-Thiel, Claudia
Mielke, Thorsten
Meierhofer, David
Timmermann, Bernd
Müller, Franz-Josef
Walter, Jörn
Meissner, Alexander
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8279952
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8279952
Other Identifiers
ISSN
1545-9993
E-ISSN
1545-9985
DOI
10.1038/s41594-021-00603-8
