p53 deficiency induces MTHFD2 transcription to promote cell proliferation and restrain DNA damage
p53 deficiency induces MTHFD2 transcription to promote cell proliferation and restrain DNA damage
About this item
Full title
Author / Creator
Li, Gen , Wu, Jun , Li, Le and Jiang, Peng
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
Cancer cells acquire metabolic reprogramming to satisfy their high biogenetic demands, but little is known about how metabolic remodeling enables cancer cells to survive stress associated with genomic instability. Here, we show that the mitochondrial methylenetetrahydrofolate dehydrogenase (MTHFD2) is transcriptionally suppressed by p53, and its up...
Alternative Titles
Full title
p53 deficiency induces MTHFD2 transcription to promote cell proliferation and restrain DNA damage
Authors, Artists and Contributors
Author / Creator
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8285905
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8285905
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.2019822118
