Metabolic determinants of cancer cell sensitivity to canonical ferroptosis inducers
Metabolic determinants of cancer cell sensitivity to canonical ferroptosis inducers
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Author / Creator
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publication information
Publisher
New York: Nature Publishing Group US
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More information
Scope and Contents
Contents
Cancer cells rewire their metabolism and rely on endogenous antioxidants to mitigate lethal oxidative damage to lipids. However, the metabolic processes that modulate the response to lipid peroxidation are poorly defined. Using genetic screens, we compared metabolic genes essential for proliferation upon inhibition of cystine uptake or glutathione...
Alternative Titles
Full title
Metabolic determinants of cancer cell sensitivity to canonical ferroptosis inducers
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8299533
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8299533
Other Identifiers
ISSN
1552-4450
E-ISSN
1552-4469
DOI
10.1038/s41589-020-0613-y
