Differentiation of exhausted CD8+ T cells after termination of chronic antigen stimulation stops sho...
Differentiation of exhausted CD8+ T cells after termination of chronic antigen stimulation stops short of achieving functional T cell memory
About this item
Full title
Author / Creator
Tonnerre, Pierre , Wolski, David , Subudhi, Sonu , Aljabban, Jihad , Hoogeveen, Ruben C. , Damasio, Marcos , Drescher, Hannah K. , Bartsch, Lea M. , Tully, Damien C. , Sen, Debattama R. , Bean, David J. , Brown, Joelle , Torres-Cornejo, Almudena , Robidoux, Maxwell , Kvistad, Daniel , Alatrakchi, Nadia , Cui, Ang , Lieb, David , Cheney, James A. , Gustafson, Jenna , Lewis-Ximenez, Lia L. , Massenet-Regad, Lucile , Eisenhaure, Thomas , Aneja, Jasneet , Haining, W. Nicholas , Chung, Raymond T. , Hacohen, Nir , Allen, Todd M. , Kim, Arthur Y. and Lauer, Georg M.
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
T cell exhaustion is associated with failure to clear chronic infections and malignant cells. Defining the molecular mechanisms of T cell exhaustion and reinvigoration is essential to improving immunotherapeutic modalities. Here we confirmed pervasive phenotypic, functional and transcriptional differences between memory and exhausted antigen-specif...
Alternative Titles
Full title
Differentiation of exhausted CD8+ T cells after termination of chronic antigen stimulation stops short of achieving functional T cell memory
Authors, Artists and Contributors
Author / Creator
Wolski, David
Subudhi, Sonu
Aljabban, Jihad
Hoogeveen, Ruben C.
Damasio, Marcos
Drescher, Hannah K.
Bartsch, Lea M.
Tully, Damien C.
Sen, Debattama R.
Bean, David J.
Brown, Joelle
Torres-Cornejo, Almudena
Robidoux, Maxwell
Kvistad, Daniel
Alatrakchi, Nadia
Cui, Ang
Lieb, David
Cheney, James A.
Gustafson, Jenna
Lewis-Ximenez, Lia L.
Massenet-Regad, Lucile
Eisenhaure, Thomas
Aneja, Jasneet
Haining, W. Nicholas
Chung, Raymond T.
Hacohen, Nir
Allen, Todd M.
Kim, Arthur Y.
Lauer, Georg M.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8323980
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8323980
Other Identifiers
ISSN
1529-2908
E-ISSN
1529-2916
DOI
10.1038/s41590-021-00982-6
