Oncogenic gene fusions in nonneoplastic precursors as evidence that bacterial infection can initiate...
Oncogenic gene fusions in nonneoplastic precursors as evidence that bacterial infection can initiate prostate cancer
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Publisher
United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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Contents
Prostate adenocarcinoma is the second most commonly diagnosed cancer in men worldwide, and the initiating factors are unknown. Oncogenic TMPRSS2:ERG (ERG+) gene fusions are facilitated by DNA breaks and occur in up to 50% of prostate cancers. Infection-driven inflammation is implicated in the formation of ERG+ fusions, and we hypothesized that thes...
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Full title
Oncogenic gene fusions in nonneoplastic precursors as evidence that bacterial infection can initiate prostate cancer
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8364155
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8364155
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.2018976118
