FTO downregulation mediated by hypoxia facilitates colorectal cancer metastasis
FTO downregulation mediated by hypoxia facilitates colorectal cancer metastasis
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Author / Creator
Ruan, Dan-Yun , Li, Ting , Wang, Ying-Nan , Meng, Qi , Li, Yang , Yu, Kai , Wang, Min , Lin, Jin-Fei , Luo, Li-Zhi , Wang, De-Shen , Lin, Jun-Zhong , Bai, Long , Liu, Ze-Xian , Zhao, Qi , Wu, Xiang-Yuan , Ju, Huai-Qiang and Xu, Rui-Hua
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Fat mass and obesity-associated protein (FTO), an N6-methyladenosine (m
6
A) demethylase, participates in tumor progression and metastasis in many malignancies, but its role in colorectal cancer (CRC) is still unclear. Here, we found that FTO protein levels, but not RNA levels, were downregulated in CRC tissues. Reduced FTO protein expression...
Alternative Titles
Full title
FTO downregulation mediated by hypoxia facilitates colorectal cancer metastasis
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8376648
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8376648
Other Identifiers
ISSN
0950-9232,1476-5594
E-ISSN
1476-5594
DOI
10.1038/s41388-021-01916-0
