GABA from reactive astrocytes impairs memory in mouse models of Alzheimer's disease
GABA from reactive astrocytes impairs memory in mouse models of Alzheimer's disease
About this item
Full title
Author / Creator
Jo, Seonmi , Yarishkin, Oleg , Hwang, Yu Jin , Chun, Ye Eun , Park, Mijeong , Woo, Dong Ho , Bae, Jin Young , Kim, Taekeun , Lee, Jaekwang , Chun, Heejung , Park, Hyun Jung , Lee, Da Yong , Hong, Jinpyo , Kim, Hye Yun , Oh, Soo-Jin , Park, Seung Ju , Lee, Hyo , Yoon, Bo-Eun , Kim, YoungSoo , Jeong, Yong , Shim, Insop , Bae, Yong Chul , Cho, Jeiwon , Kowall, Neil W , Ryu, Hoon , Hwang, Eunmi , Kim, Daesoo and Lee, C Justin
Publisher
New York: Nature Publishing Group US
Journal title
Language
English
Formats
Publication information
Publisher
New York: Nature Publishing Group US
Subjects
More information
Scope and Contents
Contents
In Alzheimer's disease, increased MAOB activity in reactive astrocytes leads to enhanced GABA release, and blockage of this pathway ameliorates memory dysfunction in mouse models.
In Alzheimer's disease (AD), memory impairment is the most prominent feature that afflicts patients and their families. Although reactive astrocytes have been observed...
Alternative Titles
Full title
GABA from reactive astrocytes impairs memory in mouse models of Alzheimer's disease
Authors, Artists and Contributors
Author / Creator
Yarishkin, Oleg
Hwang, Yu Jin
Chun, Ye Eun
Park, Mijeong
Woo, Dong Ho
Bae, Jin Young
Kim, Taekeun
Lee, Jaekwang
Chun, Heejung
Park, Hyun Jung
Lee, Da Yong
Hong, Jinpyo
Kim, Hye Yun
Oh, Soo-Jin
Park, Seung Ju
Lee, Hyo
Yoon, Bo-Eun
Kim, YoungSoo
Jeong, Yong
Shim, Insop
Bae, Yong Chul
Cho, Jeiwon
Kowall, Neil W
Ryu, Hoon
Hwang, Eunmi
Kim, Daesoo
Lee, C Justin
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8385452
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8385452
Other Identifiers
ISSN
1078-8956
E-ISSN
1546-170X
DOI
10.1038/nm.3639
