Inhibition of elastase enhances the adjuvanticity of alum and promotes anti–SARS-CoV-2 systemic and...
Inhibition of elastase enhances the adjuvanticity of alum and promotes anti–SARS-CoV-2 systemic and mucosal immunity
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Author / Creator
Kim, Eunsoo , Attia, Zayed , Woodfint, Rachel M. , Zeng, Cong , Kim, Sun Hee , Steiner, Haley E. , Shukla, Rajni Kant , Liyanage, Namal P. M. , Ghimire, Shristi , Li, Jianrong , Renukaradhya, Gourapura J. , Satoskar, Abhay R. , Amer, Amal O. , Liu, Shan-Lu , Cormet-Boyaka, Estelle and Boyaka, Prosper N.
Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
Alum, used as an adjuvant in injected vaccines, promotes T helper 2 (Th2) and serum antibody (Ab) responses. However, it fails to induce secretory immunoglobulin (Ig) A (SIgA) in mucosal tissues and is poor in inducing Th1 and cell-mediated immunity. Alum stimulates interleukin 1 (IL-1) and the recruitment of myeloid cells, including neutrophils. W...
Alternative Titles
Full title
Inhibition of elastase enhances the adjuvanticity of alum and promotes anti–SARS-CoV-2 systemic and mucosal immunity
Authors, Artists and Contributors
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8403952
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8403952
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.2102435118
