Breast cancer dependence on MCL-1 is due to its canonical anti-apoptotic function
Breast cancer dependence on MCL-1 is due to its canonical anti-apoptotic function
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London: Nature Publishing Group UK
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Language
English
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London: Nature Publishing Group UK
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High levels of the anti-apoptotic BCL-2 family member MCL-1 are frequently found in breast cancer and, appropriately, BH3-mimetic drugs that specifically target MCL-1’s function in apoptosis are in development as anti-cancer therapy. MCL-1 also has reported non-canonical roles that may be relevant in its tumour-promoting effect. Here we investigate...
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Breast cancer dependence on MCL-1 is due to its canonical anti-apoptotic function
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8408186
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https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8408186
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ISSN
1350-9047
E-ISSN
1476-5403
DOI
10.1038/s41418-021-00773-4
