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Effect of severe renal impairment on the pharmacokinetics of brigatinib

Effect of severe renal impairment on the pharmacokinetics of brigatinib

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8426299

Effect of severe renal impairment on the pharmacokinetics of brigatinib

About this item

Full title

Effect of severe renal impairment on the pharmacokinetics of brigatinib

Publisher

New York: Springer US

Journal title

Investigational new drugs, 2021-10, Vol.39 (5), p.1306-1314

Language

English

Formats

Publication information

Publisher

New York: Springer US

More information

Scope and Contents

Contents

Summary
Background
Brigatinib, a next-generation anaplastic lymphoma kinase (ALK) inhibitor, targets activated, mutant forms of ALK and overcomes mechanisms of resistance to the ALK inhibitors crizotinib, ceritinib, and alectinib. Brigatinib is approved in multiple countries for treatment of patients with ALK-positive non–small cell lung canc...

Alternative Titles

Full title

Effect of severe renal impairment on the pharmacokinetics of brigatinib

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8426299

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8426299

Other Identifiers

ISSN

0167-6997

E-ISSN

1573-0646

DOI

10.1007/s10637-021-01095-5

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