IL-1β–driven osteoclastogenic Tregs accelerate bone erosion in arthritis
IL-1β–driven osteoclastogenic Tregs accelerate bone erosion in arthritis
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Author / Creator
Levescot, Anaïs , Chang, Margaret H. , Schnell, Julia , Nelson-Maney, Nathan , Yan, Jing , Martínez-Bonet, Marta , Grieshaber-Bouyer, Ricardo , Lee, Pui Y. , Wei, Kevin , Blaustein, Rachel B. , Morris, Allyn , Wactor, Alexandra , Iwakura, Yoichiro , Lederer, James A. , Rao, Deepak A. , Charles, Julia F. and Nigrovic, Peter A.
Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
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Publication information
Publisher
United States: American Society for Clinical Investigation
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Scope and Contents
Contents
IL-1β is a proinflammatory mediator with roles in innate and adaptive immunity. Here we show that IL-1β contributes to autoimmune arthritis by inducing osteoclastogenic capacity in Tregs. Using mice with joint inflammation arising through deficiency of the IL-1 receptor antagonist (Il1rn-/-), we observed that IL-1β blockade attenuated disease more...
Alternative Titles
Full title
IL-1β–driven osteoclastogenic Tregs accelerate bone erosion in arthritis
Authors, Artists and Contributors
Author / Creator
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Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8439607
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8439607
Other Identifiers
ISSN
1558-8238,0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI141008
