Autism-linked Cullin3 germline haploinsufficiency impacts cytoskeletal dynamics and cortical neuroge...
Autism-linked Cullin3 germline haploinsufficiency impacts cytoskeletal dynamics and cortical neurogenesis through RhoA signaling
About this item
Full title
Author / Creator
Amar, Megha , Pramod, Akula Bala , Yu, Nam-Kyung , Herrera, Victor Munive , Qiu, Lily R. , Moran-Losada, Patricia , Zhang, Pan , Trujillo, Cleber A. , Ellegood, Jacob , Urresti, Jorge , Chau, Kevin , Diedrich, Jolene , Chen, Jiaye , Gutierrez, Jessica , Sebat, Jonathan , Ramanathan, Dhakshin , Lerch, Jason P. , Yates, John R. , Muotri, Alysson R. and Iakoucheva, Lilia M.
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
E3-ubiquitin ligase Cullin3 (
Cul3
) is a high confidence risk gene for autism spectrum disorder (ASD) and developmental delay (DD). To investigate how
Cul3
mutations impact brain development, we generated a haploinsufficient
Cul3
mouse model using CRISPR/Cas9 genome engineering.
Cul3
mutant mice exhibited social and cogniti...
Alternative Titles
Full title
Autism-linked Cullin3 germline haploinsufficiency impacts cytoskeletal dynamics and cortical neurogenesis through RhoA signaling
Authors, Artists and Contributors
Author / Creator
Pramod, Akula Bala
Yu, Nam-Kyung
Herrera, Victor Munive
Qiu, Lily R.
Moran-Losada, Patricia
Zhang, Pan
Trujillo, Cleber A.
Ellegood, Jacob
Urresti, Jorge
Chau, Kevin
Diedrich, Jolene
Chen, Jiaye
Gutierrez, Jessica
Sebat, Jonathan
Ramanathan, Dhakshin
Lerch, Jason P.
Yates, John R.
Muotri, Alysson R.
Iakoucheva, Lilia M.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8443683
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8443683
Other Identifiers
ISSN
1359-4184
E-ISSN
1476-5578
DOI
10.1038/s41380-021-01052-x
