Automated production of CCR5-negative CD4+-T cells in a GMP-compatible, clinical scale for treatment...
Automated production of CCR5-negative CD4+-T cells in a GMP-compatible, clinical scale for treatment of HIV-positive patients
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Full title
Author / Creator
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
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Publication information
Publisher
London: Nature Publishing Group UK
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Scope and Contents
Contents
Ex-vivo gene editing in T lymphocytes paves the way for novel concepts of immunotherapy. One of those strategies is directed at the protection of CD4
+
-T helper cells from HIV infection in HIV-positive individuals. To this end, we have developed and optimised a
CCR5
-targeting TALE nuclease, CCR5-Uco-hetTALEN, mediating high-efficiency...
Alternative Titles
Full title
Automated production of CCR5-negative CD4+-T cells in a GMP-compatible, clinical scale for treatment of HIV-positive patients
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8455337
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8455337
Other Identifiers
ISSN
0969-7128
E-ISSN
1476-5462
DOI
10.1038/s41434-021-00259-5
