Characterization of Plasma Membrane Localization and Phosphorylation Status of Organic Anion Transpo...
Characterization of Plasma Membrane Localization and Phosphorylation Status of Organic Anion Transporting Polypeptide (OATP) 1B1 c.521 T>C Nonsynonymous Single-Nucleotide Polymorphism
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Publisher
New York: Springer US
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Language
English
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Publisher
New York: Springer US
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Contents
Purpose
Membrane transport protein organic anion transporting polypeptide (OATP) 1B1 mediates hepatic uptake of many drugs (e.g. statins). The OATP1B1 c.521 T > C (p. V174A) polymorphism has reduced transport activity. Conflicting
in vitro
results exist regarding whether V174A-OATP1B1 has reduced plasma membrane localization; no such data...
Alternative Titles
Full title
Characterization of Plasma Membrane Localization and Phosphorylation Status of Organic Anion Transporting Polypeptide (OATP) 1B1 c.521 T>C Nonsynonymous Single-Nucleotide Polymorphism
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8456979
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8456979
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ISSN
0724-8741
E-ISSN
1573-904X
DOI
10.1007/s11095-019-2634-3
