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Nuclear receptor NR5A2 negatively regulates cell proliferation and tumor growth in nervous system ma...

Nuclear receptor NR5A2 negatively regulates cell proliferation and tumor growth in nervous system ma...

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8488649

Nuclear receptor NR5A2 negatively regulates cell proliferation and tumor growth in nervous system malignancies

About this item

Full title

Nuclear receptor NR5A2 negatively regulates cell proliferation and tumor growth in nervous system malignancies

Publisher

United States: National Academy of Sciences

Journal title

Proceedings of the National Academy of Sciences - PNAS, 2021-09, Vol.118 (39), p.1-12

Language

English

Formats

Publication information

Publisher

United States: National Academy of Sciences

More information

Scope and Contents

Contents

Nervous system malignancies are characterized by rapid progression and poor survival rates. These clinical observations underscore the need for novel therapeutic insights and pharmacological targets. To this end, here, we identify the orphan nuclear receptor NR5A2/LRH1 as a negative regulator of cancer cell proliferation and promising pharmacologic...

Alternative Titles

Full title

Nuclear receptor NR5A2 negatively regulates cell proliferation and tumor growth in nervous system malignancies

Identifiers

Primary Identifiers

Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8488649

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8488649

Other Identifiers

ISSN

0027-8424

E-ISSN

1091-6490

DOI

10.1073/pnas.2015243118

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