Chemotherapy-induced transposable elements activate MDA5 to enhance haematopoietic regeneration
Chemotherapy-induced transposable elements activate MDA5 to enhance haematopoietic regeneration
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Full title
Author / Creator
Clapes, Thomas , Polyzou, Aikaterini , Prater, Pia , Sagar , Morales-Hernández, Antonio , Ferrarini, Mariana Galvao , Kehrer, Natalie , Lefkopoulos, Stylianos , Bergo, Veronica , Hummel, Barbara , Obier, Nadine , Maticzka, Daniel , Bridgeman, Anne , Herman, Josip S. , Ilik, Ibrahim , Klaeylé, Lhéanna , Rehwinkel, Jan , McKinney-Freeman, Shannon , Backofen, Rolf , Akhtar, Asifa , Cabezas-Wallscheid, Nina , Sawarkar, Ritwick , Rebollo, Rita , Grün, Dominic and Trompouki, Eirini
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Haematopoietic stem cells (HSCs) are normally quiescent, but have evolved mechanisms to respond to stress. Here, we evaluate haematopoietic regeneration induced by chemotherapy. We detect robust chromatin reorganization followed by increased transcription of transposable elements (TEs) during early recovery. TE transcripts bind to and activate the...
Alternative Titles
Full title
Chemotherapy-induced transposable elements activate MDA5 to enhance haematopoietic regeneration
Authors, Artists and Contributors
Author / Creator
Polyzou, Aikaterini
Prater, Pia
Sagar
Morales-Hernández, Antonio
Ferrarini, Mariana Galvao
Kehrer, Natalie
Lefkopoulos, Stylianos
Bergo, Veronica
Hummel, Barbara
Obier, Nadine
Maticzka, Daniel
Bridgeman, Anne
Herman, Josip S.
Ilik, Ibrahim
Klaeylé, Lhéanna
Rehwinkel, Jan
McKinney-Freeman, Shannon
Backofen, Rolf
Akhtar, Asifa
Cabezas-Wallscheid, Nina
Sawarkar, Ritwick
Rebollo, Rita
Grün, Dominic
Trompouki, Eirini
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8492473
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8492473
Other Identifiers
ISSN
1465-7392,1476-4679
E-ISSN
1476-4679
DOI
10.1038/s41556-021-00707-9
