BCL-2 Inhibitor ABT-737 Effectively Targets Leukemia-Initiating Cells with Differential Regulation o...
BCL-2 Inhibitor ABT-737 Effectively Targets Leukemia-Initiating Cells with Differential Regulation of Relevant Genes Leading to Extended Survival in a NRAS/BCL-2 Mouse Model of High Risk-Myelodysplastic Syndrome
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Author / Creator
Gorombei, Petra , Guidez, Fabien , Ganesan, Saravanan , Chiquet, Mathieu , Pellagatti, Andrea , Goursaud, Laure , Tekin, Nilgun , Beurlet, Stephanie , Patel, Satyananda , Guerenne, Laura , Le Pogam, Carole , Setterblad, Niclas , de la Grange, Pierre , LeBoeuf, Christophe , Janin, Anne , Noguera, Maria-Elena , Sarda-Mantel, Laure , Merlet, Pascale , Boultwood, Jacqueline , Konopleva, Marina , Andreeff, Michael , West, Robert , Pla, Marika , Adès, Lionel , Fenaux, Pierre , Krief, Patricia , Chomienne, Christine , Omidvar, Nader and Padua, Rose Ann
Publisher
Basel: MDPI AG
Journal title
Language
English
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Publication information
Publisher
Basel: MDPI AG
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Scope and Contents
Contents
During transformation, myelodysplastic syndromes (MDS) are characterized by reducing apoptosis of bone marrow (BM) precursors. Mouse models of high risk (HR)-MDS and acute myelogenous leukemia (AML) post-MDS using mutant NRAS and overexpression of human BCL-2, known to be poor prognostic indicators of the human diseases, were created. We have repor...
Alternative Titles
Full title
BCL-2 Inhibitor ABT-737 Effectively Targets Leukemia-Initiating Cells with Differential Regulation of Relevant Genes Leading to Extended Survival in a NRAS/BCL-2 Mouse Model of High Risk-Myelodysplastic Syndrome
Authors, Artists and Contributors
Author / Creator
Guidez, Fabien
Ganesan, Saravanan
Chiquet, Mathieu
Pellagatti, Andrea
Goursaud, Laure
Tekin, Nilgun
Beurlet, Stephanie
Patel, Satyananda
Guerenne, Laura
Le Pogam, Carole
Setterblad, Niclas
de la Grange, Pierre
LeBoeuf, Christophe
Janin, Anne
Noguera, Maria-Elena
Sarda-Mantel, Laure
Merlet, Pascale
Boultwood, Jacqueline
Konopleva, Marina
Andreeff, Michael
West, Robert
Pla, Marika
Adès, Lionel
Fenaux, Pierre
Krief, Patricia
Chomienne, Christine
Omidvar, Nader
Padua, Rose Ann
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8508829
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8508829
Other Identifiers
ISSN
1422-0067,1661-6596
E-ISSN
1422-0067
DOI
10.3390/ijms221910658
