Breast cancer–derived GM-CSF regulates arginase 1 in myeloid cells to promote an immunosuppressive m...
Breast cancer–derived GM-CSF regulates arginase 1 in myeloid cells to promote an immunosuppressive microenvironment
About this item
Full title
Author / Creator
Su, Xinming , Xu, Yalin , Fox, Gregory C. , Xiang, Jingyu , Kwakwa, Kristin A. , Davis, Jennifer L. , Belle, Jad I. , Lee, Wen-Chih , Wong, Wing H. , Fontana, Francesca , Hernandez-Aya, Leonel F. , Kobayashi, Takayuki , Tomasson, Helen M. , Su, Junyi , Bakewell, Suzanne J. , Stewart, Sheila A. , Egbulefu, Christopher , Karmakar, Partha , Meyer, Melisa A. , Veis, Deborah J. , DeNardo, David G. , Lanza, Gregory M. , Achilefu, Samuel and Weilbaecher, Katherine N.
Publisher
United States: American Society for Clinical Investigation
Journal title
Language
English
Formats
Publication information
Publisher
United States: American Society for Clinical Investigation
Subjects
More information
Scope and Contents
Contents
Tumor-infiltrating myeloid cells contribute to the development of the immunosuppressive tumor microenvironment. Myeloid cell expression of arginase 1 (ARG1) promotes a protumor phenotype by inhibiting T cell function and depleting extracellular l-arginine, but the mechanism underlying this expression, especially in breast cancer, is poorly understo...
Alternative Titles
Full title
Breast cancer–derived GM-CSF regulates arginase 1 in myeloid cells to promote an immunosuppressive microenvironment
Authors, Artists and Contributors
Author / Creator
Xu, Yalin
Fox, Gregory C.
Xiang, Jingyu
Kwakwa, Kristin A.
Davis, Jennifer L.
Belle, Jad I.
Lee, Wen-Chih
Wong, Wing H.
Fontana, Francesca
Hernandez-Aya, Leonel F.
Kobayashi, Takayuki
Tomasson, Helen M.
Su, Junyi
Bakewell, Suzanne J.
Stewart, Sheila A.
Egbulefu, Christopher
Karmakar, Partha
Meyer, Melisa A.
Veis, Deborah J.
DeNardo, David G.
Lanza, Gregory M.
Achilefu, Samuel
Weilbaecher, Katherine N.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8516467
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8516467
Other Identifiers
ISSN
1558-8238,0021-9738
E-ISSN
1558-8238
DOI
10.1172/JCI145296
