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Neuronal defects in a human cellular model of 22q11.2 deletion syndrome

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Neuronal defects in a human cellular model of 22q11.2 deletion syndrome

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8525897

Neuronal defects in a human cellular model of 22q11.2 deletion syndrome

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New York: Nature Publishing Group US

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Contents

22q11.2 deletion syndrome (22q11DS) is a highly penetrant and common genetic cause of neuropsychiatric disease. Here we generated induced pluripotent stem cells from 15 individuals with 22q11DS and 15 control individuals and differentiated them into three-dimensional (3D) cerebral cortical organoids. Transcriptional profiling across 100 days showed...

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Full title

Neuronal defects in a human cellular model of 22q11.2 deletion syndrome

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Record Identifier

TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8525897

Permalink

https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8525897

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ISSN

1078-8956

E-ISSN

1546-170X

DOI

10.1038/s41591-020-1043-9

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