Dual-mechanism estrogen receptor inhibitors
Dual-mechanism estrogen receptor inhibitors
About this item
Full title
Author / Creator
Min, Jian , Nwachukwu, Jerome C. , Min, Charles K. , Njeri, Jacqline W. , Srinivasan, Sathish , Rangarajan, Erumbi S. , Nettles, Charles C. , Guillen, Valeria Sanabria , Ziegler, Yvonne , Yan, Shunchao , Carlson, Kathryn E. , Hou, Yingwei , Kim, Sung Hoon , Novick, Scott , Pascal, Bruce D. , Houtman, Rene , Griffin, Patrick R. , Izard, Tina , Katzenellenbogen, Benita S. , Katzenellenbogen, John A. and Nettles, Kendall W.
Publisher
United States: National Academy of Sciences
Journal title
Language
English
Formats
Publication information
Publisher
United States: National Academy of Sciences
Subjects
More information
Scope and Contents
Contents
Efforts to improve estrogen receptor-α (ER)–targeted therapies in breast cancer have relied upon a single mechanism, with ligands having a single side chain on the ligand core that extends outward to determine antagonism of breast cancer growth. Here, we describe inhibitors with two ER-targeting moieties, one of which uses an alternate structural m...
Alternative Titles
Full title
Dual-mechanism estrogen receptor inhibitors
Authors, Artists and Contributors
Author / Creator
Nwachukwu, Jerome C.
Min, Charles K.
Njeri, Jacqline W.
Srinivasan, Sathish
Rangarajan, Erumbi S.
Nettles, Charles C.
Guillen, Valeria Sanabria
Ziegler, Yvonne
Yan, Shunchao
Carlson, Kathryn E.
Hou, Yingwei
Kim, Sung Hoon
Novick, Scott
Pascal, Bruce D.
Houtman, Rene
Griffin, Patrick R.
Izard, Tina
Katzenellenbogen, Benita S.
Katzenellenbogen, John A.
Nettles, Kendall W.
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8536401
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8536401
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.2101657118
