Circulating androgen receptor gene amplification and resistance to 177Lu-PSMA-617 in metastatic cast...
Circulating androgen receptor gene amplification and resistance to 177Lu-PSMA-617 in metastatic castration-resistant prostate cancer: results of a Phase 2 trial
About this item
Full title
Author / Creator
De Giorgi, Ugo , Sansovini, Maddalena , Severi, Stefano , Nicolini, Silvia , Monti, Manuela , Gurioli, Giorgia , Foca, Flavia , Casadei, Chiara , Conteduca, Vincenza , Celli, Monica , Di Iorio, Valentina , Calistri, Daniele , Matteucci, Federica , von Eyben, Finn Edler , Attard, Gerhardt and Paganelli, Giovanni
Publisher
London: Nature Publishing Group UK
Journal title
Language
English
Formats
Publication information
Publisher
London: Nature Publishing Group UK
Subjects
More information
Scope and Contents
Contents
Background
In a Phase 2 clinical trial, we aimed to determine the lutetium-177 [
177
Lu]-PSMA-617 activity and the clinical utility of levels of plasma androgen receptor (AR) gene in patients with heavily pretreated metastatic castration-resistant prostate cancer (mCRPC).
Methods
We determined AR copy number in pretreatment plasma sa...
Alternative Titles
Full title
Circulating androgen receptor gene amplification and resistance to 177Lu-PSMA-617 in metastatic castration-resistant prostate cancer: results of a Phase 2 trial
Authors, Artists and Contributors
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8548293
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8548293
Other Identifiers
ISSN
0007-0920
E-ISSN
1532-1827
DOI
10.1038/s41416-021-01508-5
