Involvement of PBRM1 in VHL disease‑associated clear cell renal cell carcinoma and its putative rela...
Involvement of PBRM1 in VHL disease‑associated clear cell renal cell carcinoma and its putative relationship with the HIF pathway
About this item
Full title
Author / Creator
Gad, Sophie , Le Teuff, Gwenaël , Nguyen, Baptiste , Verkarre, Virginie , Duchatelle, Veronique , Molinie, Vincent , Posseme, Katia , Grandon, Benjamin , Da Costa, Melanie , Job, Bastien , Meurice, Guillaume , Droin, Nathalie , Mejean, Arnaud , Couve, Sophie , Renaud, Flore , Gardie, Betty , Teh, Bin , Richard, Stephane and Ferlicot, Sophie
Publisher
Athens: Spandidos Publications
Journal title
Language
English
Formats
Publication information
Publisher
Athens: Spandidos Publications
Subjects
More information
Scope and Contents
Contents
Von Hippel-Lindau (VHL) disease is the main cause of inherited clear-cell renal cell carcinoma (ccRCC) and is caused by germline mutations in the VHL tumor suppressor gene. Bi-allelic VHL alterations lead to inactivation of pVHL, which plays a major role by downstream activation of the hypoxia inducible factor (HIF) pathway. Somatic VHL mutations o...
Alternative Titles
Full title
Involvement of PBRM1 in VHL disease‑associated clear cell renal cell carcinoma and its putative relationship with the HIF pathway
Authors, Artists and Contributors
Author / Creator
Le Teuff, Gwenaël
Nguyen, Baptiste
Verkarre, Virginie
Duchatelle, Veronique
Molinie, Vincent
Posseme, Katia
Grandon, Benjamin
Da Costa, Melanie
Job, Bastien
Meurice, Guillaume
Droin, Nathalie
Mejean, Arnaud
Couve, Sophie
Renaud, Flore
Gardie, Betty
Teh, Bin
Richard, Stephane
Ferlicot, Sophie
Identifiers
Primary Identifiers
Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8548775
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8548775
Other Identifiers
ISSN
1792-1074
E-ISSN
1792-1082
DOI
10.3892/ol.2021.13096
