NUDT15 polymorphism and NT5C2 and PRPS1 mutations influence thiopurine sensitivity in acute lymphobl...
NUDT15 polymorphism and NT5C2 and PRPS1 mutations influence thiopurine sensitivity in acute lymphoblastic leukaemia cells
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Author / Creator
Somazu, Shinpei , Tanaka, Yoichi , Tamai, Minori , Watanabe, Atsushi , Kagami, Keiko , Abe, Masako , Harama, Daisuke , Shinohara, Tamao , Akahane, Koshi , Goi, Kumiko , Sugita, Kanji , Moriyama, Takaya , Yang, Jun , Goto, Hiroaki , Minegishi, Masayoshi , Iwamoto, Shotaro , Takita, Junko and Inukai, Takeshi
Publisher
England: John Wiley & Sons, Inc
Journal title
Language
English
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Publisher
England: John Wiley & Sons, Inc
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Scope and Contents
Contents
In chemotherapy for childhood acute lymphoblastic leukaemia (ALL), maintenance therapy consisting of oral daily mercaptopurine and weekly methotrexate is important. NUDT15 variant genotype is reportedly highly associated with severe myelosuppression during maintenance therapy, particularly in Asian and Hispanic populations. It has also been demonst...
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Full title
NUDT15 polymorphism and NT5C2 and PRPS1 mutations influence thiopurine sensitivity in acute lymphoblastic leukaemia cells
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8581340
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8581340
Other Identifiers
ISSN
1582-1838,1582-4934
E-ISSN
1582-4934
DOI
10.1111/jcmm.16981
