Glutathione peroxidase 4–regulated neutrophil ferroptosis induces systemic autoimmunity
Glutathione peroxidase 4–regulated neutrophil ferroptosis induces systemic autoimmunity
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Publisher
New York: Nature Publishing Group US
Journal title
Language
English
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Publisher
New York: Nature Publishing Group US
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Contents
The linkage between neutrophil death and the development of autoimmunity has not been thoroughly explored. Here, we show that neutrophils from either lupus-prone mice or patients with systemic lupus erythematosus (SLE) undergo ferroptosis. Mechanistically, autoantibodies and interferon-α present in the serum induce neutrophil ferroptosis through en...
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Full title
Glutathione peroxidase 4–regulated neutrophil ferroptosis induces systemic autoimmunity
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8609402
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8609402
Other Identifiers
ISSN
1529-2908
E-ISSN
1529-2916
DOI
10.1038/s41590-021-00993-3
