Conformation-sensitive antibody reveals an altered cytosolic PAS/CNBh assembly during hERG channel g...
Conformation-sensitive antibody reveals an altered cytosolic PAS/CNBh assembly during hERG channel gating
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Publisher
United States: National Academy of Sciences
Journal title
Language
English
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Publisher
United States: National Academy of Sciences
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Scope and Contents
Contents
The human ERG (hERG) K⁺ channel has a crucial function in cardiac repolarization, and mutations or channel block can give rise to long QT syndrome and catastrophic ventricular arrhythmias. The cytosolic assembly formed by the Per-Arnt-Sim (PAS) and cyclic nucleotide binding homology (CNBh) domains is the defining structural feature of hERG and rela...
Alternative Titles
Full title
Conformation-sensitive antibody reveals an altered cytosolic PAS/CNBh assembly during hERG channel gating
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Record Identifier
TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8612226
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8612226
Other Identifiers
ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.2108796118
