TIM-3 restrains anti-tumour immunity by regulating inflammasome activation
TIM-3 restrains anti-tumour immunity by regulating inflammasome activation
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Publisher
London: Nature Publishing Group UK
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Language
English
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Publisher
London: Nature Publishing Group UK
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Contents
T cell immunoglobulin and mucin-containing molecule 3 (TIM-3), first identified as a molecule expressed on interferon-γ producing T cells
1
, is emerging as an important immune-checkpoint molecule, with therapeutic blockade of TIM-3 being investigated in multiple human malignancies. Expression of TIM-3 on CD8
+
T cells in the tumour mic...
Alternative Titles
Full title
TIM-3 restrains anti-tumour immunity by regulating inflammasome activation
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8627694
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8627694
Other Identifiers
ISSN
0028-0836
E-ISSN
1476-4687
DOI
10.1038/s41586-021-03626-9
