Optogenetic stimulation of glutamatergic neurons in the cuneiform nucleus controls locomotion in a m...
Optogenetic stimulation of glutamatergic neurons in the cuneiform nucleus controls locomotion in a mouse model of Parkinson’s disease
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United States: National Academy of Sciences
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Language
English
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Publisher
United States: National Academy of Sciences
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In Parkinson’s disease (PD), the loss of midbrain dopaminergic cells results in severe locomotor deficits, such as gait freezing and akinesia. Growing evidence indicates that these deficits can be attributed to the decreased activity in the mesencephalic locomotor region (MLR), a brainstem region controlling locomotion. Clinicians are exploring the...
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Full title
Optogenetic stimulation of glutamatergic neurons in the cuneiform nucleus controls locomotion in a mouse model of Parkinson’s disease
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TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8639376
Permalink
https://devfeature-collection.sl.nsw.gov.au/record/TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_8639376
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ISSN
0027-8424
E-ISSN
1091-6490
DOI
10.1073/pnas.2110934118
